*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH9802500
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
                          3,3-dimethyl-7-oxo-6-((phenylacetyl) amino)-
                          (2S-(2-alpha,5-alpha,6-beta))-, compd. with
                          alpha-phenylbenzenemethanamine, hydrochloride (1:1:1)
CAS REGISTRY NUMBER     : 1538-11-0
LAST UPDATED            : 198402
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C16-H18-N2-O4-S.C13-H13-N.Cl-H
MOLECULAR WEIGHT        : 554.15
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzhydrylamine penicillin hydrochloride
   * Chlorhydrate du penicillate de benzhydrylamine
   * Orencil hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - changes in motor activity (specific assay)
   Behavioral - coma
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 12,565,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 12,565,1954
 
                            *** END OF RECORD ***