*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH9200000
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
                          3,3-dimethyl-7-oxo-6-(butylthio acetamido)-
CAS REGISTRY NUMBER     : 6192-29-6
BEILSTEIN REFERENCE NO. : 0044346
REFERENCE               : 4-27-00-05887 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C14-H22-N2-O4-S2
MOLECULAR WEIGHT        : 346.50
WISWESSER LINE NOTATION : T45 ANV ESTJ CMV1S4 F1 F1 GVQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Butylmercaptomethylpenicillin
   * n-Butylthiomethylpenicillin
   * Penicillin BT
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 101 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/year: 34,126,1949
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 11500 ug/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/year: 34,126,1949
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/year: 34,126,1949
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 15600 ug/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/year: 34,126,1949
 
                            *** END OF RECORD ***