*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XG2004700
CHEMICAL NAME           : Thalictrum revolutum DC, root extract
SUBSTANCE DEFINITION :
   Plant belonging to the family Ranunculaceae
REFERENCE :
   LLOYA2 Lloydia.  (Cincinnati, OH)  V.1-41, 1938-78.  For publisher
   information, see JNPRDF.  Volume(issue)/page/year: 26,229,1963
LAST UPDATED            : 199506
DATA ITEMS CITED        : 4
COMPOUND DESCRIPTOR     : Natural Product
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   LLOYA2 Lloydia.  (Cincinnati, OH)  V.1-41, 1938-78.  For publisher
   information, see JNPRDF.  Volume(issue)/page/year: 26,229,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18200 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   LLOYA2 Lloydia.  (Cincinnati, OH)  V.1-41, 1938-78.  For publisher
   information, see JNPRDF.  Volume(issue)/page/year: 26,229,1963
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   LLOYA2 Lloydia.  (Cincinnati, OH)  V.1-41, 1938-78.  For publisher
   information, see JNPRDF.  Volume(issue)/page/year: 26,229,1963
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Gastrointestinal - nausea or vomiting
REFERENCE :
   LLOYA2 Lloydia.  (Cincinnati, OH)  V.1-41, 1938-78.  For publisher
   information, see JNPRDF.  Volume(issue)/page/year: 26,229,1963
 
                            *** END OF RECORD ***