*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH5100000
CHEMICAL NAME           : Theophylline, 7-(2,3-dihydroxypropyl)-
CAS REGISTRY NUMBER     : 479-18-5
OTHER CAS REGISTRY NOS. : 52756-53-3
BEILSTEIN REFERENCE NO. : 0284563
REFERENCE               : 5-26-14-00070 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C10-H14-N4-O4
MOLECULAR WEIGHT        : 254.28
WISWESSER LINE NOTATION : T56 BN DN FNVNVJ B1YQ1Q F1 H1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AFI-Phyllin
   * Aristophyllin
   * Astmamasit
   * Astrophyllin
   * Circain
   * Circair
   * Coronal
   * Coronarin
   * Corphyllin
   * COR-theophylline
   * 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
   * Dihydroxypropyl theopylin
   * Dihydroxypropyl theophylline
   * (1,2-Dihydroxy-3-propyl)thiophyllin
   * 7-(2,3-Dihydroxypropyl)theophylline
   * 1,3-Dimethyl-7-(2,3-dihydroxypropyl)xanthine
   * 7-(2,3-Dioxypropyl)theophylline
   * Diphyllin
   * Diprofillin
   * Diprofilline
   * Diprophyllin
   * Diprophylline
   * Dyphylline
   * Glyfyllin
   * Glyphyllin
   * Glyphylline
   * Hidroxiteofillina
   * Hiphyllin
   * Hyphylline
   * Lufyllin
   * Neophyllin
   * Neophylline
   * Neophyllin M
   * Neostenovasan
   * Neothylline
   * Neotilina
   * Neo-vasophylline
   * Neufil
   * Neutrafil
   * Neutrafillina
   * Neutraphyllin
   * Neutraphylline
   * Neutroxantina
   * Propyphyllin
   * Protheophylline
   * Purifilin
   * 1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl
   * Sibephyllin
   * Sibephylline
   * Silbephylline
   * Solufilin
   * Solufyllin
   * Soluphyllin
   * Synthophylline
   * Tefilan
   * Theal
   * Theal ampules
   * Thefylan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 35,266,1946
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1253 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 230,194,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 860 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 230,194,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1954 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 116,343,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 195 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   STRAAA Strahlentherapie.  (Urban & Schwarzenberg, Postfach 202440, D-8000
   Munich 2, Fed. Rep. Ger.) V.1-    1912-  Volume(issue)/page/year:
   127,245,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1052 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 6,601,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1080 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,288,1970

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80405
       No. of Facilities: 68 (estimated)
       No. of Industries: 1
       No. of Occupations: 6
       No. of Employees: 2770 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80405
       No. of Facilities: 38 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 795 (estimated)
       No. of Female Employees: 486 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***