*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH5085000
CHEMICAL NAME           : Theophylline, 8-chloro-, compd. with
                          4-(diphenylmethoxy)-1-methylpiperidine (1:1)
CAS REGISTRY NUMBER     : 606-90-6
LAST UPDATED            : 198610
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H23-N-O.C7-H7-Cl-N4-O2
MOLECULAR WEIGHT        : 496.06
WISWESSER LINE NOTATION : T56 BM DN FNVNVJ CG F1 H1 &T6NTJ A1 DOYR&R
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Diphenylpyralin-8-chlor-theophyllinat
   * Diphenylpyraline teoclate
   * Kolton
   * Piprinhydrinate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,334,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 86 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,334,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,334,1982
 
                            *** END OF RECORD ***