*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CI7664000
CHEMICAL NAME           : L-Ascorbic acid, compd. with N(sup
                          4)-(7-chloro-4-quinolinyl)-N(sup 1),N(sup 1)-diethyl-
                          1,4-pentanediamine (2:1)
CAS REGISTRY NUMBER     : 38305-48-5
LAST UPDATED            : 198502
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H26-Cl-N3.2C6-H8-O6
MOLECULAR WEIGHT        : 672.20
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Chloroquine ascorbate
   * Chloroquine diascorbate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1570 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 7,753,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 203 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 7,753,1973
 
                            *** END OF RECORD ***