*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CF1988000
CHEMICAL NAME           : L-Arginine, mixt. with
                          (6R-(6-alpha,7-beta(Z)))-1-((7-(((2-amino-4-thiazolyl
                          )(methoxyimino)
                          acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2
                          .0)oct-2-en-3-yl)meth yl)-1- methylpyrrolidinium
                          hydroxide, inner salt, dihydrochloride
CAS REGISTRY NUMBER     : 143892-90-4
LAST UPDATED            : 199712
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C6-H14-N4-O2.C19-H24-N6-O5-S2.2Cl-H
MOLECULAR WEIGHT        : 727.77
SYNONYMS/TRADE NAMES :
   * BMY-28142 L-arginine dihydrochloride
   * Cefepime dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42 gm/kg/28D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 45,620,1992
 
                            *** END OF RECORD ***