*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CE1057900
CHEMICAL NAME           : 6a-alpha-Aporphin-9-ol, 1,2,10-trimethoxy-
CAS REGISTRY NUMBER     : 2169-44-0
LAST UPDATED            : 198208
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H23-N-O4
MOLECULAR WEIGHT        : 341.44
WISWESSER LINE NOTATION : T C6666 1A Q KN&TT&J EO1 FQ K1 PO1 QO1
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * 4H-Dibenzo(de,g)quinolin-9-ol,  
   5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (S)-
   * Lauroscholtzine
   * N-Methyllaurotetanine
   * (+)-N-Methyllaurotetanine
   * Rogersine
   * 1,2,10-Trimethoxy-6a-alpha-aporphin-9-ol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 38,537,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 38,537,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 38,537,1980
 
                            *** END OF RECORD ***