*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CE0350000
CHEMICAL NAME : 6a-beta-Aporphine, 1,2-dimethoxy-
CAS REGISTRY NUMBER : 475-83-2
LAST UPDATED : 199707
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C19-H21-N-O2
MOLECULAR WEIGHT : 295.41
WISWESSER LINE NOTATION : T C6666 1A Q KN&TT&J K1 PO1 QO1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-,
(R)-
* l-5,6-Dimethoxyaporphine
* (R)-1,2-Dimethoxyaporphine
* (-)-Nucipherine
* Nuciferin
* Nuciferine
* (-)-Nuciferine
* l-Nuciferine
* Sanjoinine E
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Sense Organs and Special Senses (Eye) - ptosis
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 197,261,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 240 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Nutritional and Gross Metabolic - body temperature decrease
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 197,261,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 83 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 61,813,1972
*** END OF RECORD ***