*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XF0791000
CHEMICAL NAME           : 11,16,18,19-Tetraoxapentacyclo(12.2.2.1(sup
                          6,9).0(sup 1,15).0(10,12))nonadeca-6,8-diene-7-
                          carboxaldehyde,
                          2-(acetyloxy)-12-methyl-4-(1-methylethenyl)-17-oxo-,
                          (1R-(1R*,2S*,4S*,10R*,12R*,14R*,15R*))-
CAS REGISTRY NUMBER     : 78697-56-0
BEILSTEIN REFERENCE NO. : 4339458
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H24-O8
MOLECULAR WEIGHT        : 416.46
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Lophotoxin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARPTDI Annual Review of Pharmacology and Toxicology.  (Annual Reviews, Inc.,
   POB 10139, Palo Alto, CA 94303)  V.16-    1976- Volume(issue)/page/year:
   26,117,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   212,1512,1981
 
                            *** END OF RECORD ***