*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XB8800000
CHEMICAL NAME           : Tetradecanoylhydroxamic acid,
                          N-fluoren-2-yl-N-tetradecanoyl-
CAS REGISTRY NUMBER     : 63224-46-4
BEILSTEIN REFERENCE NO. : 2927100
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C41-H63-N-O3
MOLECULAR WEIGHT        : 618.05
WISWESSER LINE NOTATION : L B656 HHJ ENV13&OV13
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * N-Myristoyloxy-N-myristoyl-2-aminofluorene
   * N-Tetradecanoyl-N-tetradecanoyloxy-2-aminofluorene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 157 mg/kg/5W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,1461,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 100 umol/L/5H
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 16,284,1975

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***