*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WN3325000
CHEMICAL NAME : Succinimide, N-methyl-2-phenyl-
CAS REGISTRY NUMBER : 86-34-0
BEILSTEIN REFERENCE NO. : 0155329
REFERENCE : 5-21-11-00188 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C11-H11-N-O2
MOLECULAR WEIGHT : 189.23
WISWESSER LINE NOTATION : T5VNVTJ B1 DR
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Epimid
* Fenosuccimide
* Lifene
* Methylphenylsuccinimide
* 1-Methyl-3-phenylpyrrolidin-2,5-dione
* 1-Methyl-3-phenyl-2,5-pyrrolidinedione
* N-Methyl-alpha-phenylsuccinimide
* N-Methyl-2-phenyl-succinimide
* Milontin
* Mirotin
* Phenosuccimide
* Phensuximide
* Phenylsuximide
* PM 334
* 2,5-Pyrrolidinedione, 1-methyl-3-phenyl-
* Succitimal
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 23,377,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 485 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.9- 1974- Volume(issue)/page/year: 13,465,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 795 mg/kg/7D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - hematuria
Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 6,349,1986
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 666 mg/kg
SEX/DURATION : female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
2,61,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE : 1533 mg/kg
SEX/DURATION : female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 38,438,1979
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 100 ug/L
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 116,867,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4457
No. of Facilities: 46 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 279 (estimated)
No. of Female Employees: 46 (estimated)
*** END OF RECORD ***