*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WM9800000
CHEMICAL NAME           : Succinic acid, monoethyl ester, monoester with
                          erythromycin
CAS REGISTRY NUMBER     : 1264-62-6
OTHER CAS REGISTRY NOS. : 41342-53-4
BEILSTEIN REFERENCE NO. : 0077638
REFERENCE               : 4-18-00-07416 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C43-H75-N-O16
MOLECULAR WEIGHT        : 862.19
WISWESSER LINE NOTATION : T-14-VO GVTJ C2 DQ D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ
                          CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Erythrocin ethyl succinate
   * Erythromycin, ethyl succinate
   * Erythromycin, mono(ethyl succinate)
   * Pediamycin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 420 mg/kg/7D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Liver - other changes
REFERENCE :
   CMAJAX Canadian Medical Association Journal.  (Canadian Medical Assoc., POB
   8650, Ottawa, ON K1G 0G8, Canada)  V.1-    1911-  Volume(issue)/page/year:
   129,411,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 5714 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 10,616,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4167 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   9,445,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,126,1982

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M0949
       No. of Facilities: 113 (estimated)
       No. of Industries: 2
       No. of Occupations: 7
       No. of Employees: 3065 (estimated)
       No. of Female Employees: 1433 (estimated)

 
                            *** END OF RECORD ***