*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WK2236000
CHEMICAL NAME           : D-Streptamine,
                          O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2
                          )-O-5-deoxy-3-C-
                          (hydroxymethyl)-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(
                          aminoiminomethyl)-, sulfate (2:3) (salt)
CAS REGISTRY NUMBER     : 5490-27-7
LAST UPDATED            : 199801
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C21-H41-N7-O12.3/2H2-O4-S
MOLECULAR WEIGHT        : 730.74
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Didromycin
   * Didromycine
   * Dihydrostreptomycin sesquisulfate
   * Dihydrostreptomycin 3/2 sulfate
   * Panstreptin
   * Streptomycin, dihydro-, sulfate (2:3) (salt)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 841 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABANAE Antibiotics Annual.  (New York, NY)  1953-60.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: 4,564,1956/1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 186 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABANAE Antibiotics Annual.  (New York, NY)  1953-60.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: 4,564,1956/1967
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 19598 mg/kg/78D-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Ear) - change in acuity
REFERENCE :
   ABANAE Antibiotics Annual.  (New York, NY)  1953-60.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: 4,564,1956/1957

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1292
       No. of Facilities: 413 (estimated)
       No. of Industries: 2
       No. of Occupations: 6
       No. of Employees: 4059 (estimated)
       No. of Female Employees: 2035 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***