*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WJ5775000
CHEMICAL NAME : 4,4'-Stilbenediol, alpha,alpha'-diethyl-,
dipropionate, (E)-
CAS REGISTRY NUMBER : 130-80-3
BEILSTEIN REFERENCE NO. : 2632126
REFERENCE : 4-06-00-06857 (Beilstein Handbook Reference)
LAST UPDATED : 199707
DATA ITEMS CITED : 20
MOLECULAR FORMULA : C24-H28-O4
MOLECULAR WEIGHT : 380.52
WISWESSER LINE NOTATION : 2VOR DY2&UY2&R DOV2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
Hormone
SYNONYMS/TRADE NAMES :
* Clinestrol
* Cyren B
* DESD
* Dibestil
* trans-4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol dipropionate
* alpha,alpha'-Diethyl-4,4'-stilbenediol, dipropionate
* trans-alpha,alpha'-Diethyl-4,4'-stilbenediol dipropionate
* Diethylstilbene dipropionate
* alpha,alpha'-Diethyl-4,4'-stilbenediol dipropionyl ester
* Diethylstilbestrol dipropionate
* Dihydroxydiethylstilbene dipropionate
* 4,4'-Dihydroxy-alpha,beta-diethylstilbene dipropionate
* Dipropionato de estilbene
* p,p'-Dipropionoxy-trans-alpha,beta-diethylstilbene
* Estilben
* Estilbin
* Estroben DF
* Estrobene DP
* Estrogenin
* Estrostilben
* Euvestin
* Gynolett
* Horfemine
* Neo-oestranol II
* New-oestranol II
* Oestrogynaedron
* Orestol
* Pabestrol D
* Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis-, dipropanoate, (E)-
* Sinciclan
* 4,4'-Stilbenediol, alpha,alpha'-diethyl-, dipropionate, trans-
* Stilbestrol, diethyl dipropionate
* Stilbestrol dipropionate
* Stilbestrol propionate
* Stilbestronate
* Stilboestrol dipropionate
* Stilboestrol DP
* Stilbofax
* Stilronate
* Synestrol
* Synoestron
* Syntestrin
* Syntestrine
* Tauripar B
* Vetoestrol
* Willestrol
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - tumors
Endocrine - changes in growth hormone
REFERENCE :
HMMRA2 Hormone and Metabolic Research. (Georg Thieme Verlag, Postfach 732,
D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1969- Volume(issue)/page/year:
7,228,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 113 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - tumors
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981. For
publisher information, see EJCODS. Volume(issue)/page/year: 5,99,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
RSABAC Revista de la Sociedad Argentina de Biologia. (Sociedad Argentina de
Biologia, Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428
Buenos Aires, Argentina) V.1- 1925- Volume(issue)/page/year:
25,215,1949
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 160 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
BECCAN Annual Report--Cancer Research Campaign. (Cancer Research Campaign,
2 Carlton House Terrace, London SW1Y 5AR, UK) V.1- 1924-
Volume(issue)/page/year: 30,60,1952
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 133 mg/kg/32W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - tumors
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.41- 1956- Volume(issue)/page/year: 81,898,1976
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 60 ug/kg
SEX/DURATION : female 3-4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 26(1),1,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 500 ug/kg
SEX/DURATION : female 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 60,287,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 70 ug/kg
SEX/DURATION : female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 26(1),1,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 20 ug/kg
SEX/DURATION : female 3-4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 26(1),1,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE : 200 ug/kg
SEX/DURATION : female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 164,2372,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cattle
DOSE : 200 ng/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 18,359,1969
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 100 mg/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 31,97,1979
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1300 nmol/L
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English
translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1- 1967- Volume(issue)/page/year: 16(2),24,1982
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1300 nmol/L
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English
translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1- 1967- Volume(issue)/page/year: 16(2),24,1982
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 144,27,1985
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 7500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,7,1995
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 5 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,499,1982
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 5 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,499,1982
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 21,173,1979
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-aneuploidy
*** END OF RECORD ***