*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WH1318000
CHEMICAL NAME : Spiro(naphthalene-2(1H),2'-oxirane)-3'-carboxaldehyde
, 3,5,6,7,8,8a-hexahydro-7-acetoxy-5,6-
epoxy-3',8,8a-trimethyl-3-oxo-
CAS REGISTRY NUMBER : 56299-00-4
LAST UPDATED : 199410
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C17-H20-O6
MOLECULAR WEIGHT : 320.37
WISWESSER LINE NOTATION : T B366 CO JV KUTJ EOV1 F1 G1 IOV1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* PRT
* PR toxin
* PR toxine
* Toxin (Penicillium roquefortii)
* Toxin PR
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 115 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - other changes
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 25,111,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11600 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 20,433,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8200 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 20,433,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 72 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - fluid intake
Behavioral - changes in motor activity (specific assay)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,369,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - fluid intake
Behavioral - changes in motor activity (specific assay)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,369,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,116,1981
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg/52D-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
MYCPAH Mycopathologia. (Kluwer Academic Pub. Group, Distribution Centre,
POB 322, 3300 AH Dordrecht, Netherlands) V.1- 1938-
Volume(issue)/page/year: 78,125,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 139 mg/kg/52D-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
MYCPAH Mycopathologia. (Kluwer Academic Pub. Group, Distribution Centre,
POB 322, 3300 AH Dordrecht, Netherlands) V.1- 1938-
Volume(issue)/page/year: 78,125,1982
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 625 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,79,1984
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,536,1978
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 100 ug/disc
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
36,445,1976
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 2 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,45,1979
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 30 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,45,1979
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 5 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,45,1979
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 25 umol/L
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008
Paris, France) V.1- 1978- Volume(issue)/page/year: 2,273,1979
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 10 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
14,207,1976
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 35 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
18,153,1977
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis; S
cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Weakly Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
*** END OF RECORD ***