*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WJ3540000
CHEMICAL NAME           : 4-Stilbenamine, (E)-
CAS REGISTRY NUMBER     : 4309-66-4
BEILSTEIN REFERENCE NO. : 2208344
REFERENCE               : 4-12-00-03399 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C14-H13-N
MOLECULAR WEIGHT        : 195.28
WISWESSER LINE NOTATION : ZR DIUIR -T
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * trans-4-Aminostilbene
   * Benzenamine, 4-(2-phenylethenyl)-, (E)-
   * (E)-4-(2-Phenylethenyl)benzenamine
   * trans-4-Stilbene
   * trans-4-N-Stilbenamine
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg/13W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Gastrointestinal - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   24,128,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 26 mg/kg/4W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - prostate tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   24,128,1964
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 63 mg/kg/6W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   PTRMAD Philosophical Transactions of the Royal Society of London, Series A:
   Mathematical & Physical Sciences.  (Royal Soc., 6 Carlton House Terrace,
   London SW1Y 5AG, UK)  V.178-    1887-  Volume(issue)/page/year: 241,147,1948
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg/7W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   PTRMAD Philosophical Transactions of the Royal Society of London, Series A:
   Mathematical & Physical Sciences.  (Royal Soc., 6 Carlton House Terrace,
   London SW1Y 5AG, UK)  V.178-    1887-  Volume(issue)/page/year: 241,147,1948
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 70,2281,1973
 
                            *** END OF RECORD ***