*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WH1307300
CHEMICAL NAME           : Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione,
                          2,7-difluoro-
CAS REGISTRY NUMBER     : 89391-50-4
LAST UPDATED            : 199712
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C15-H8-F2-N2-O2
MOLECULAR WEIGHT        : 286.25
SYNONYMS/TRADE NAMES :
   * AL 1576
   * Alcon 1576
   * 2,7-Difluorospiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione
   * HOE 843
   * Imirestat
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg/14D-I
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
   etc.)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year: 36(1,
   Pt 2),137,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 700 mg/kg/14D-I
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
   etc.)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year: 36(1,
   Pt 2),137,1997
 
                            *** END OF RECORD ***