*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WG9701000
CHEMICAL NAME           : Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridi
                          n)-3(1H)-one, 2,3'a,4',5,5',6,6',6a,
                          6b,7,7',7'a,8,11,11a,11b-hexadecahydro-3',6',10,11b-t
                          etramethyl-
CAS REGISTRY NUMBER     : 14410-98-1
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C27-H41-N-O2
MOLECULAR WEIGHT        : 411.69
WISWESSER LINE NOTATION : L D6 B566 FX OV MUTJ A1 E1 F-& CT56 BOX FMTJ D1 H1
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 11-Deoxojervine-4-en-3-one
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 38 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   41CIAR "Effects of Poisonous Plants on Livestock, Proceedings of a Joint
   U.S.-Australian Symposium on Poisonous Plants, Logan, UT, 1977," Keeler,
   R.F., et al. eds., New York, Academic Press, Inc., 1978
   Volume(issue)/page/year: -,409,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 15 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   41CIAR "Effects of Poisonous Plants on Livestock, Proceedings of a Joint
   U.S.-Australian Symposium on Poisonous Plants, Logan, UT, 1977," Keeler,
   R.F., et al. eds., New York, Academic Press, Inc., 1978
   Volume(issue)/page/year: -,409,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 38 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   41CIAR "Effects of Poisonous Plants on Livestock, Proceedings of a Joint
   U.S.-Australian Symposium on Poisonous Plants, Logan, UT, 1977," Keeler,
   R.F., et al. eds., New York, Academic Press, Inc., 1978
   Volume(issue)/page/year: -,409,1978
 
                            *** END OF RECORD ***