*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WG9634812
CHEMICAL NAME           : Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane
                          ), 2'-methyl-, hydrochloride, hydrate (2:1), cis-
CAS REGISTRY NUMBER     : 153504-70-2
LAST UPDATED            : 199703
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C10-H17-N-O-S.Cl-H.1/2H2-O
MOLECULAR WEIGHT        : 244.78
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Cevimeline hydrochloride hemihydrate
   * cis-2-Methylspiro(1,3-oxathiolane-5,3')quinuclidine hydrochloride hydrate 
    (2:2:1)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 139 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #5340821
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #5340821
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #5340821
 
                            *** END OF RECORD ***