*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WE5270000
CHEMICAL NAME           : Sodium tetravanadate
CAS REGISTRY NUMBER     : 12058-74-1
LAST UPDATED            : 199701
DATA ITEMS CITED        : 29
MOLECULAR FORMULA       : O11-V4.2Na
MOLECULAR WEIGHT        : 425.74
WISWESSER LINE NOTATION :  NA2 VA4-O11
COMPOUND DESCRIPTOR     : Human
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AJSNAO American Journal of Syphilis and Neurology.  (St. Louis, MO) V.1-19,
   1917-35.  For publisher information, see AJSGA3. Volume(issue)/page/year:
   1,347,1917
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human
DOSE/DURATION           : 7 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SAIGBL Sangyo Igaku.  Japanese Journal of Industrial Health.  (Nippon Sangyo
   Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
   Japan)  V.1-    1959-  Volume(issue)/page/year: 13,263,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AJSNAO American Journal of Syphilis and Neurology.  (St. Louis, MO) V.1-19,
   1917-35.  For publisher information, see AJSGA3. Volume(issue)/page/year:
   1,347,1917
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 58 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AJSNAO American Journal of Syphilis and Neurology.  (St. Louis, MO) V.1-19,
   1917-35.  For publisher information, see AJSGA3. Volume(issue)/page/year:
   1,347,1917
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AJSNAO American Journal of Syphilis and Neurology.  (St. Louis, MO) V.1-19,
   1917-35.  For publisher information, see AJSGA3. Volume(issue)/page/year:
   1,347,1917
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AJSNAO American Journal of Syphilis and Neurology.  (St. Louis, MO) V.1-19,
   1917-35.  For publisher information, see AJSGA3. Volume(issue)/page/year:
   1,347,1917
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AJSNAO American Journal of Syphilis and Neurology.  (St. Louis, MO) V.1-19,
   1917-35.  For publisher information, see AJSGA3. Volume(issue)/page/year:
   1,347,1917
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AJSNAO American Journal of Syphilis and Neurology.  (St. Louis, MO) V.1-19,
   1917-35.  For publisher information, see AJSGA3. Volume(issue)/page/year:
   1,347,1917
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 117 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AJSNAO American Journal of Syphilis and Neurology.  (St. Louis, MO) V.1-19,
   1917-35.  For publisher information, see AJSGA3. Volume(issue)/page/year:
   1,347,1917
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJSNAO American Journal of Syphilis and Neurology.  (St. Louis, MO) V.1-19,
   1917-35.  For publisher information, see AJSGA3. Volume(issue)/page/year:
   1,347,1917

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
   Washington, DC, National Academy of Sciences, 1972-77
   Volume(issue)/page/year: V,46,1974

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 0.05 mg(V2O5)/m3 JAN 1993
   
   OEL-BELGIUM:TWA 0.05 mg(V2O5)/m3 JAN 1993
   
   OEL-DENMARK:TWA 0.03 mg(V2O5)/m3 JAN 1993
   
   OEL-FINLAND:TWA 0.5 mg(V2O5)/m3 JAN 1993
   
   OEL-FRANCE:TWA 0.05 mg(V2O5)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.05 mg(V2O5)/m3 JAN 1993
   
   OEL-HUNGARY:TWA 0.05 mg(V2O5)/m3;STEL 0.1 mg(V205)/m3 JAN 1993
   
   OEL-JAPAN:TWA 0.5 mg(V2O5)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.5 mg(V2O5)/m3 JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.25 mg(V205)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.5 mg(V2O5)/m3 JAN 1993
   
   OEL-SWEDEN:STEL 0.05 mg(V2O5)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.2 mg(V2O5)/m3  (dust) JAN 1993
   
   OEL-SWITZERLAND:TWA 0.05 mg(V2O5)/m3;STEL 0.25 mg(V2O5)/m3  JAN 1993
   
   OEL-TURKEY:TWA 0.5 mg(V2O5)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.05 mg(V2O5)/m3  (dust) JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.5 mg(V2O5)/m3 JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO VANADIUM (as V2O5), resp dust/fume-air:CL 0.05 mg/m3/15M
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

 
                            *** END OF RECORD ***