*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WE1900000
CHEMICAL NAME           : Sodium sulfide
CAS REGISTRY NUMBER     : 16721-80-5
OTHER CAS REGISTRY NOS. : 1310-76-5
LAST UPDATED            : 199710
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : H-Na-S
MOLECULAR WEIGHT        : 56.06
WISWESSER LINE NOTATION : .NA..S H
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Sodium bisulfide
   * Sodium hydrogen sulfide
   * Sodium hydrosulfide
   * Sodium mercaptan
   * Sodium mercaptide
   * Sodium sulfhydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   38,973,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 1,327,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 3,99,1954
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 67500 ug/kg/3D-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Biochemical - Metabolism (Intermediary) - amino acids (including renal
   excretion)
REFERENCE :
   NRTXDN Neurotoxicology.  (Intox Press, Inc., POB 34075, Little Rock, AR
   72203)  V.1-    1979-  Volume(issue)/page/year: 11,93,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg/5D-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Biochemical - Metabolism (Intermediary) - amino acids (including renal
   excretion)
REFERENCE :
   NRTXDN Neurotoxicology.  (Intox Press, Inc., POB 34075, Little Rock, AR
   72203)  V.1-    1979-  Volume(issue)/page/year: 11,93,1990
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 90,91,1981
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 50 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 90,91,1981
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Multiple routes
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2000 ppm
REFERENCE :
   ACBIEF Actualidades Biologicas (Medellin, Colombia).  (Universidad de
   Antioquia, Departamento de Biologia, Apartado Aereo 1226, Medellin,
   Colombia)  V.1-    1972-  Volume(issue)/page/year: 14(52),48,1985

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83515
       No. of Facilities: 94 (estimated)
       No. of Industries: 5
       No. of Occupations: 10
       No. of Employees: 359 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83515
       No. of Facilities: 577 (estimated)
       No. of Industries: 18
       No. of Occupations: 34
       No. of Employees: 12517 (estimated)
       No. of Female Employees: 4278 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***