*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VV9100000
CHEMICAL NAME : Silicic acid, beryllium zinc salt
CAS REGISTRY NUMBER : 39413-47-3
OTHER CAS REGISTRY NOS. : 63089-82-7
LAST UPDATED : 199712
DATA ITEMS CITED : 43
WISWESSER LINE NOTATION : BE ZN SI-O4
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Beryllium zinc silicate
* Zinc beryllium silicate
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,519,1950
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
20,778,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 17 mg(Be)/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53-
1966- Volume(issue)/page/year: 62,49,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 88,89,1969
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
JBSUAK Journal of Bone and Joint Surgery, British Volume. (10 Shattuck St.,
Boston, MA 02115) V.30- 1948- Volume(issue)/page/year: 36,543,1954
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 5,221,1946
*** REVIEWS ***
ACGIH TLV-SUSPECTED HUMAN CARCINOGEN
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997
ACGIH TLV-TWA 0.002 mg(Be)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 1,17,1972
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 23,143,1980
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,41,1993
TOXICOLOGY REVIEW
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-BELGIUM:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-DENMARK:TWA 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-FINLAND:TWA 0.002 mg(Be)/m3;STEL 0.006 mg(Be)/m3;Carcinogen JAN 1993
OEL-FRANCE:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-INDIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-JAPAN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-POLAND:TWA 0.001 mg(Be)/m3 JAN 1993
OEL-RUSSIA:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWEDEN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 0.002 mg(Be)/m3;STEL 0.005 mg(Be)/m3 JAN 1993
OEL-TURKEY:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.002 mg(Be)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
*** END OF RECORD ***