*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VV4000000
CHEMICAL NAME : Silane, beta-(3,4-epoxycyclohexyl)ethyltrimethoxy-
CAS REGISTRY NUMBER : 3388-04-3
LAST UPDATED : 199712
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C11-H22-O4-Si
MOLECULAR WEIGHT : 246.42
WISWESSER LINE NOTATION : T36 BOTJ E2-SI-O1&O1&O1
COMPOUND DESCRIPTOR : Tumorigen
Organometallic
Primary Irritant
SYNONYMS/TRADE NAMES :
* A 186 (coupling agent)
* E 6250
* Epoxycyclohexylethyl trimethoxy silane
* beta-(3,4-Epoxycyclohexyl)ethyltrimethoxysilane
* KBM 303
* NUCA 186
* S 530
* Sila-Ace S 530
* Silane Y-4086
* Silicone A-186
* Silquest A 186
* Union carbide A-186
* Y 4086
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg
REACTION SEVERITY : Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/17/1972
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc.,
605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year:
8,11,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc.,
605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year:
8,11,1974
TYPE OF TEST : LC - Lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >290 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc.,
605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year:
8,11,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 6300 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 2/11/1964
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1587 gm/kg/76W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
12,579,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9076
No. of Facilities: 367 (estimated)
No. of Industries: 17
No. of Occupations: 23
No. of Employees: 15389 (estimated)
No. of Female Employees: 3865 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***