*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VT5970000
CHEMICAL NAME           : Senecionanium,
                          8,12,18-trihydroxy-4-methyl-11,16-dioxo-
CAS REGISTRY NUMBER     : 26782-43-4
LAST UPDATED            : 199510
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C19-H28-N-O7
MOLECULAR WEIGHT        : 382.48
WISWESSER LINE NOTATION : T55-12- 1A Q EK IOVY OVO BUTJ DQ E1 KUYQ1 M1 NQ N1
COMPOUND DESCRIPTOR     : Tumorigen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Hydroxysenkirkine
   * Senkirkine, hydroxy-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   49,665,1972

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 10,265,1976

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 10,265,1976

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

   TOXICOLOGY REVIEW
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 60,1171,1976

 
                            *** END OF RECORD ***