*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VT5723000
CHEMICAL NAME           : Senecionan-11,16-dione, 12-hydroxy-, and
                          seneciphylline mixture (80:20)
LAST UPDATED            : 198912
DATA ITEMS CITED        : 1
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * 12-Hydroxysenecionan-11,16-dione and  
   13,19-didehydro-12-hydroxysenecion-11,16-dione mixture
   * Senecionine and seneciphylline mixture (80:20)
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 1-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 77,461,1988
 
                            *** END OF RECORD ***