*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VS2878300
CHEMICAL NAME           : 9,10-Secocholesta-5,7,10(19)-triene-1,3,24,25-tetrol,
                          (1-alpha,3-beta,5Z,7E,24R)-
CAS REGISTRY NUMBER     : 56142-94-0
LAST UPDATED            : 199806
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C27-H44-O4
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (24R)-24-Hydroxycalcitriol
   *   (1-alpha,3-beta,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24,25
     -tetrol
   * Ro 21-7729
   * 1-alpha,24(R),25-Trihydroxyvitamin D3
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 812 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 17,4615,1989
 
                            *** END OF RECORD ***