*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VM2975000
CHEMICAL NAME : Rutin
CAS REGISTRY NUMBER : 153-18-4
OTHER CAS REGISTRY NOS. : 115888-40-9
BEILSTEIN REFERENCE NO. : 0075455
REFERENCE : 5-18-05-00519 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C27-H30-O16
MOLECULAR WEIGHT : 610.57
WISWESSER LINE NOTATION : T66 BO EVJ CR CQ DQ& GQ IQ DO- BT6OTJ CQ DQ EQ F1O-
BT6OTJ CQ DQ EQ F1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Bioflavonoid
* Birutan
* C.I. 75730
* Eldrin
* Flavone, 3,3',4',5,7-pentahydroxy-, 3-(O-rhamnosylglucoside)
* Globulariacitrin
* Globularicitrin
* Glucopyranoside, quercetin-3 6-O-(6-deoxy-alpha-L-mannopyranosyl)-,
beta-D-
* Glucopyranoside, quercetin-3 6-O-alpha-L-rhamnopyranosyl-, beta-D
* Ilixathin
* Melin
* Myrticalorin
* Myrticolorin
* Myticolorin
* Osyritin
* Osyritrin
* Oxyritin
* Paliuroside
* 3,3',4',5,7-Pentahydroxyflavone-3-rutinoside
* Phytomelin
* Quercetin,
3-(6-0-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside)
* Quercetin 3-rhamnoglucoside
* Quercetin rhamnoglucosine
* Quercetin, 3-(6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranoside)
* Quercetin 3-rutinoside
* Rutabion
* Rutinic acid
* Rutinoside,
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-yl
* Rutinoside, quercetin-3, beta-
* Rutoside
* Rutozyd
* Sophorin
* Tanrutin
* USAF CF-5
* Violaquercitrin
* Vitamin P
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6,
Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 19,207,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 39,556,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6,
Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 19,207,1980
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 973 gm/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 25,95,1984
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 80 ug/plate
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
23,669,1985
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 100 mg/L
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 18,223,1980
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 50 mmol/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
32,423,1994
TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION : 2 gm/kg
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
25,9,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80506
No. of Facilities: 68 (estimated)
No. of Industries: 1
No. of Occupations: 6
No. of Employees: 2770 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80506
No. of Facilities: 19 (estimated)
No. of Industries: 1
No. of Occupations: 9
No. of Employees: 934 (estimated)
No. of Female Employees: 506 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***