*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VO6125000
CHEMICAL NAME           : Salicylic acid, phenyl ester
CAS REGISTRY NUMBER     : 118-55-8
BEILSTEIN REFERENCE NO. : 0393969
REFERENCE               : 4-10-00-00154 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C13-H10-O3
MOLECULAR WEIGHT        : 214.23
WISWESSER LINE NOTATION : QR BVOR
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Fenylester kyseliny salicylove
   * Phenyl salicylate
   * Salol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 14,837,1976
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CBCCT* "Summary Tables of Biological Tests," National Research Council
   Chemical-Biological Coordination Center.  (National Academy of Science
   Library, 2101 Constitution Ave., NW, Washington, DC 20418)
   Volume(issue)/page/year: 6,149,1954
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   RMSRA6 Revue Medicale de la Suisse Romande.  (Societe Medicale de La Suisse
   Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland)  V.1-    1881-
   Volume(issue)/page/year: 15,561,1895
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   OCMJAJ Osaka City Medical Journal.  (Osaka City Medical Center, 1-4-54,
   Asahi-machi, Abeno-ku, Osaka 545, Japan)  V.1-    1954-
   Volume(issue)/page/year: 12,23,1966
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 7-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   OCMJAJ Osaka City Medical Journal.  (Osaka City Medical Center, 1-4-54,
   Asahi-machi, Abeno-ku, Osaka 545, Japan)  V.1-    1954-
   Volume(issue)/page/year: 12,23,1966
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 7-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   OCMJAJ Osaka City Medical Journal.  (Osaka City Medical Center, 1-4-54,
   Asahi-machi, Abeno-ku, Osaka 545, Japan)  V.1-    1954-
   Volume(issue)/page/year: 12,23,1966

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80479
       No. of Facilities: 241 (estimated)
       No. of Industries: 3
       No. of Occupations: 8
       No. of Employees: 2943 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80479
       No. of Facilities: 471 (estimated)
       No. of Industries: 4
       No. of Occupations: 11
       No. of Employees: 5712 (estimated)
       No. of Female Employees: 2297 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***