*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VM2654000
CHEMICAL NAME           : Ruthenium oxide
CAS REGISTRY NUMBER     : 12036-10-1
LAST UPDATED            : 199701
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : O2-Ru
MOLECULAR WEIGHT        : 133.07
WISWESSER LINE NOTATION : .RU..O2
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4580 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(1),46,1981
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 34 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   41HTAH "Aktual'nye Problemy Gigieny Truda.  Current Problems of Labor
   Hygiene," Tarasenko, N.Y., ed., Moscow, Pervyi Moskovskii Meditsinskii
   Inst., 1978  Volume(issue)/page/year: -,36,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5570 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(1),46,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3050 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(1),46,1981
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21400 ug/m3/17W-I
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(1),46,1981
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 21400 ug/m3/17W-I
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(1),46,1981

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - T0521
       No. of Facilities: 19 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 57 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - T0521
       No. of Facilities: 10 (estimated)
       No. of Industries: 2
       No. of Occupations: 2
       No. of Employees: 208 (estimated)
       No. of Female Employees: 86 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***