*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VL6500000
CHEMICAL NAME           : RU 67
CAS REGISTRY NUMBER     : 71503-78-1
LAST UPDATED            : 198903
DATA ITEMS CITED        : 4
COMPOUND DESCRIPTOR     : Drug
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 851 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TVLMB8 Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta.
   Transactions of the Volgograd State Medical Institute.  (Volgogradskii
   Gosudarstvennyi Meditskinskii Institut, Volgograd, USSR)  1961-
   Volume(issue)/page/year: 30,190,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 794 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TVLMB8 Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta.
   Transactions of the Volgograd State Medical Institute.  (Volgogradskii
   Gosudarstvennyi Meditskinskii Institut, Volgograd, USSR)  1961-
   Volume(issue)/page/year: 30,190,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 758 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TVLMB8 Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta.
   Transactions of the Volgograd State Medical Institute.  (Volgogradskii
   Gosudarstvennyi Meditskinskii Institut, Volgograd, USSR)  1961-
   Volume(issue)/page/year: 30,190,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 645 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TVLMB8 Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta.
   Transactions of the Volgograd State Medical Institute.  (Volgogradskii
   Gosudarstvennyi Meditskinskii Institut, Volgograd, USSR)  1961-
   Volume(issue)/page/year: 30,190,1977
 
                            *** END OF RECORD ***