*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VJ2702500
CHEMICAL NAME           : Ricin A chain
SUBSTANCE DEFINITION :
   A ribosomal inhibitory protein, which is a component of the immunoconjugate
   CD5 plus
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 12,113,1993
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg/10D-I
TOXIC EFFECTS :
   Blood - changes in leukocyte (WBC) count
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 12,113,1993
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 ug/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   IJPYEW International Journal of Pharmacognosy.  (Swets & Zeitlinger, POB
   825, 2160 SZ Lisse, Netherland)  V.29-    1991-  Volume(issue)/page/year:
   34,151,1996
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 16 ug/kg
SEX/DURATION            : female 12-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Fertility - abortion
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   IJPYEW International Journal of Pharmacognosy.  (Swets & Zeitlinger, POB
   825, 2160 SZ Lisse, Netherland)  V.29-    1991-  Volume(issue)/page/year:
   34,151,1996
 
                            *** END OF RECORD ***