*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VH7175000
CHEMICAL NAME           : Retronecine
CAS REGISTRY NUMBER     : 480-85-3
LAST UPDATED            : 199009
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C8-H13-N-O2
MOLECULAR WEIGHT        : 155.22
WISWESSER LINE NOTATION : T55 AN CUTJ D1Q FQ
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * 1H-Pyrrolizine-7-methanol, 2,3,5,7a-tetrahydro-1-hydroxy-, (1R-trans)-
   * Retronecin
   * (+)-Retronecine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1311 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   RETOAE Research Today.  (Indianapolis, IN)  V.1-16, 1944-60.  Discontinued.
   Volume(issue)/page/year: 5,53,1949
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 634 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 75,78,1942
 
                            *** END OF RECORD ***