*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VH6420000
CHEMICAL NAME           : Retinamide, N-(4-hydroxyphenyl)-
CAS REGISTRY NUMBER     : 65646-68-6
BEILSTEIN REFERENCE NO. : 5769490
LAST UPDATED            : 199712
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C26-H33-N-O2
MOLECULAR WEIGHT        : 391.60
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Fenretinide
   * N-(4-Hydroxyphenyl)retinamide
   * Retinoic acid p-hydroxyphenylamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 180 mg/kg/18D-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - retinal changes (pigmentary
   depositions, retinitis, other)
REFERENCE :
   AROPAW Archives of Ophthalmology (Chicago).  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610)  New series: V.1-44(3), 1929-50; V.64-    1960-
   Volume(issue)/page/year: 104,69,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 210 mg/kg/2W-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - retinal changes (pigmentary
   depositions, retinitis, other)
REFERENCE :
   AROPAW Archives of Ophthalmology (Chicago).  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610)  New series: V.1-44(3), 1929-50; V.64-    1960-
   Volume(issue)/page/year: 104,69,1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8388 mg/kg/21D-I
TOXIC EFFECTS :
   Blood - changes in other cell count (unspecified)
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 63,1359,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2138 mg/kg/21D-I
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 63,1359,1979
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 10-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   IJEPEI International Journal of Experimental Pathology.  (Blackwell
   Scientific Publications Ltd., POB 88, Oxford, OX2 0NE, United kingdom) V.71-
      1990-  Volume(issue)/page/year: 73,551,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 400 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 45,175,1992
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Mammary gland
DOSE/DURATION           : 10 umol/L
REFERENCE :
   NUCADQ Nutrition and Cancer.  (Franklin Institute Press, POB 2266,
   Phildelphia, PA 19103) V.1-    1978-  Volume(issue)/page/year: 7,105,1985

                          *** STATUS IN U.S. ***
 
   NTP Carcinogenesis studies; on test (prechronic studies), October 1997

 
                            *** END OF RECORD ***