*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VC3213500
CHEMICAL NAME           : Quinoline,
                          2-((4-((2-(1H-tetrazol-5-ylmethyl)phenyl)methoxy)phen
                          oxy)methyl)-
CAS REGISTRY NUMBER     : 120128-20-3
BEILSTEIN REFERENCE NO. : 3573814
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C25-H21-N5-O2
MOLECULAR WEIGHT        : 423.51
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * RG 12525
   * 2-((4-((2-(1H-Tetrazol-5-ylmethyl)phenyl)methoxy)phenoxy)methyl)quinoline
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42 gm/kg/15W-I
TOXIC EFFECTS :
   Musculoskeletal - joints
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 15,72,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 58240 mg/kg/26W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - effect on menstrual cycle
   Blood - other changes
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   28,129,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 72800 mg/kg/26W-I
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   28,129,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 14560 mg/kg/26W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   28,129,1995
 
                            *** END OF RECORD ***