*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB2635000
CHEMICAL NAME           : Quinoline,
                          7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-,
                          sulfate (1:1)
CAS REGISTRY NUMBER     : 132-73-0
LAST UPDATED            : 199112
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C18-H26-Cl-N3.H2-O4-S
MOLECULAR WEIGHT        : 418.00
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline sulfate (1:1)
   * N(sub 4)-(7-Chloro-4-quinolinyl)-N(sub 1),N(sub  
   1)-diethyl-1,4-pentanediamine
   * Chloroquine sulfate
   * Chloroquin sulfate
   * Cisplaquin
   * Lariago
   * Melubrin
   * Nivaquine
   * 1,4-Pentanediamine, N(sub 4)-(7-chloro-4-quinolinyl)-N(sub 1),N(sub  
   1)-diethyl-, sulfate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 154 mg/kg/11W-I
TOXIC EFFECTS :
   Skin and Appendages - hair
REFERENCE :
   ARDEAC Archives of Dermatology.  (AMA, 535 N. Dearborn St., Chicago, IL
   60610)  V.82-    1960-  Volume(issue)/page/year: 121,1164,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - coma
   Cardiac - cardiomyopathy including infarction
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   29,23,1991
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 222,311,1989
 
                            *** END OF RECORD ***