*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB2625000
CHEMICAL NAME           : Quinoline,
                          7-chloro-4((4-(diethylamino)-1-methylbutyl)amino)-,
                          phosphate (1:1)
CAS REGISTRY NUMBER     : 1446-17-9
LAST UPDATED            : 199201
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C18-H26-Cl-N3.H3-O4-P
MOLECULAR WEIGHT        : 417.92
WISWESSER LINE NOTATION : T66 BNJ EMY1&3N2&2 IG &P-O4
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Araten phosphate
   * Chloroquine, phosphate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 43 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   JFSCAS Journal of Forensic Sciences.  (American Soc. for Testing and
   Materials, 1916 Race St., Philadelphia, PA 19103)  V.1-    1956-
   Volume(issue)/page/year: 5,201,1965
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2740 mg/kg/39W
TOXIC EFFECTS :
   Behavioral - muscle weakness
REFERENCE :
   ARPAAQ Archives of Pathology.  (Chicago, IL)  V.5(3)-50(3), 1928-50;
   V.70-99, 1960-75.  For publisher information, see APLMAS.
   Volume(issue)/page/year: 93,209,1972
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 27,95,1961
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 2660 mg/kg
SEX/DURATION            : female 2-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Effects on Newborn - other neonatal measures or effects
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   AROTAA Archives of Otolaryngology.  (AMA, 535 N. Dearborn St., Chicago, IL
   60610)  V.1-52, 1925-50; V.72-    1960-  Volume(issue)/page/year:
   80,407,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 455 mg/kg
SEX/DURATION            : female 1-13 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   AROTAA Archives of Otolaryngology.  (AMA, 535 N. Dearborn St., Chicago, IL
   60610)  V.1-52, 1925-50; V.72-    1960-  Volume(issue)/page/year:
   80,407,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 420 mg/kg
SEX/DURATION            : female 1-6 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   AROTAA Archives of Otolaryngology.  (AMA, 535 N. Dearborn St., Chicago, IL
   60610)  V.1-52, 1925-50; V.72-    1960-  Volume(issue)/page/year:
   80,407,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25 mg/kg
SEX/DURATION            : female 18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 31,173,1985
 
                            *** END OF RECORD ***