*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VC0340000
CHEMICAL NAME : 6-Quinolinemethanol,
1,2,3,4-tetrahydro-2-((isopropylamino)methyl)-7-nitro
-
CAS REGISTRY NUMBER : 21738-42-1
BEILSTEIN REFERENCE NO. : 0485597
REFERENCE : 5-22-11-00475 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C14-H21-N3-O3
MOLECULAR WEIGHT : 279.38
WISWESSER LINE NOTATION : T66 BMT&J C1MY1&1 H1Q INW
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* 6-Hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinoli
ne
* 2-((Isopropylamino)methyl)-7-nitro-1,2,3,4-tetrahydro-6-quinolinemethanol
* Mansil
* Oxamniquine
* 6-Quinolinemethanol,
1,2,3,4-tetrahydro-2-(((1-methylethyl)amino)methyl)-7-nitro-
* 1,2,3,4-Tetrahydro-2-((isopropylamino)methyl)-7-nitro-6-quinolinemethanol
* 1,2,3,4-Tetrahydro-2-(((1-methylethyl)amino)methyl)-7-nitro-6-quinolinem
ethanol
* UK 4261
* UK 4271
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Liver - fatty liver degeneration
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 4,229,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Liver - fatty liver degeneration
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 4,229,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Liver - fatty liver degeneration
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 4,229,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RMTSAE Revista do Instituto de Medicina Tropical de Sao Paulo. (Instituto
de Medicina Tropical de Sao Paulo, Caixa Postal 2921, Sao Paulo, Brazil)
V.1- 1959- Volume(issue)/page/year: 15(Suppl 1),1,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 650 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 4,229,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ALSMAS Acta Leidensia. (Institute of Tropical Medicine Rotterman-Leiden,
Wassenaarseweg 62, 2333 AL Leiden, Netherlands) (Suspended 1942-45); V.1-
1925/26- Volume(issue)/page/year: 57,201,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 4,229,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RMTSAE Revista do Instituto de Medicina Tropical de Sao Paulo. (Instituto
de Medicina Tropical de Sao Paulo, Caixa Postal 2921, Sao Paulo, Brazil)
V.1- 1959- Volume(issue)/page/year: 15(Suppl 1),1,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 950 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 4,229,1984
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 364 nmol/plate
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 200,1,1977
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 150 mg/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 1,211,1975
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 100 ug/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
Volume(issue)/page/year: 2,379,1986
TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 mg/kg
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 200,1,1977
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 mg/kg
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 200,1,1977
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,1,1985
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - hamster Liver
DOSE/DURATION : 4 mmol/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 46,461,1990
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 ug/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
Volume(issue)/page/year: 2,379,1986
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,1,1985
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
*** END OF RECORD ***