*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB5217500
CHEMICAL NAME           : 2(1H)-Quinolinone,
                          6-(3-(((3,4-dimethoxyphenyl)methyl)amino)-2-hydroxypr
                          opoxy)-, (+-)-
CAS REGISTRY NUMBER     : 143343-83-3
LAST UPDATED            : 199806
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C21-H24-N2-O5
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   (+-)-6-(3-(((3,4-Dimethoxyphenyl)methyl)amino)-2-hydroxypropoxy)-2(1H)-q
     uinolinone
   * (+-)-6-(2-Hydroxy-3-(veratrylamino)propoxy)carbostyril
   * OPC-18790
   * Toborinone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 24,2013,1996
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 24,2007,1996
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - muscle weakness
   Gastrointestinal - nausea or vomiting
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 24,1971,1996
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 140 mg/kg/4W-I
TOXIC EFFECTS :
   Cardiac - changes in coronary arteries
   Cardiac - pulse rate increase, without fall in BP
   Cardiac - other changes
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 24,1989,1996
 
                            *** END OF RECORD ***