*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB1999065
CHEMICAL NAME           : 3-Quinolinecarboxylic acid,
                          1,4-dihydro-1-(2,4-difluorophenyl)-6-fluoro-7-
                          (3-methyl-1-piperazinyl)-4-oxo-
CAS REGISTRY NUMBER     : 108319-06-8
BEILSTEIN REFERENCE NO. : 4301726
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C21-H18-F3-N3-O3
MOLECULAR WEIGHT        : 417.42
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * A 62254
   * T 1258
   * Temafloxacin
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 36400 mg/kg/26W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   41(Suppl 5),199,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 18200 mg/kg/26W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Musculoskeletal - joints
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   41(Suppl 5),214,1993
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 60 ug/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 37,213,1993
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 ug/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 37,213,1993
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 ug/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 37,213,1993
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 20 mg/L
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 37,213,1993
 
                            *** END OF RECORD ***