*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB0230000
CHEMICAL NAME           : Quinoline,
                          7-bromo-4-((4-(dimethylamino)-1-methylbutyl)amino)-,
                          diphosphate
LAST UPDATED            : 199606
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C18-H26-Br-N3.2H3-O4-P
MOLECULAR WEIGHT        : 560.38
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 7-Bromo-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline diphosphate
   * SN 7373
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 72 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,387,1946
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 140 mg/kg/7D-I
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,387,1946
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 1500 mg/kg/15D-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Related to Chronic Data - death
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,387,1946
 
                            *** END OF RECORD ***