*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VA2974000
CHEMICAL NAME           : 4(3H)-Quinazolinone, 3-(m-chlorophenyl)-2-methyl-
CAS REGISTRY NUMBER     : 340-94-3
BEILSTEIN REFERENCE NO. : 0228739
REFERENCE               : 5-24-03-00131 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C15-H11-Cl-N2-O
MOLECULAR WEIGHT        : 270.73
WISWESSER LINE NOTATION : T66 BN DNVJ C1 DR BG
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3-(m-Chlorophenyl)-2-methyl-4(3H)-quinazolinone
   * 2-Methyl-3-(3'-chlorphenyl)-4-chinazolinon
   * Ro 345
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 22,129,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   17,616,1962
 
                            *** END OF RECORD ***