*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VA1300000
CHEMICAL NAME           : Quinazoline,
                          4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-
CAS REGISTRY NUMBER     : 19216-56-9
BEILSTEIN REFERENCE NO. : 0768345
REFERENCE               : 5-25-13-00365 (Beilstein Handbook Reference)
LAST UPDATED            : 199703
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C19-H21-N5-O4
MOLECULAR WEIGHT        : 383.45
WISWESSER LINE NOTATION : T66 BN DNJ C- AT6N DNTJ DV- BT5OJ&& EZ HO1 IO1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
   * Furazosin
   * 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline
   * Prazosin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 20 ug/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   97,455,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1143 ug/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   AMSVAZ Acta Medica Scandinavica.  (Almqvist & Wiksell, POB 45150, S-10430
   Stockholm, Sweden) V.52-224, 1919-88.  Volume(issue)/page/year: 213,157,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 280 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - hallucinations, distorted perceptions
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,508,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 1260 ug/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,622,1978
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4734418
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   128,129,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 50,182,1987
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg/60D-I
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Vascular - BP lowering not characterized in autonomic section
   Endocrine - changes in adrenal weight
REFERENCE :
   ETPAEK Experimental and Toxicologic Pathology.  (Gustav Fischer Verlag Jena,
   Postfach 100537, D-07705 Jena, Germany)  V.44-    1992-
   Volume(issue)/page/year: 45,109,1993
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE                    : 2571 ug/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   AMSVAZ Acta Medica Scandinavica.  (Almqvist & Wiksell, POB 45150, S-10430
   Stockholm, Sweden) V.52-224, 1919-88.  Volume(issue)/page/year: 213,319,1983
 
                            *** END OF RECORD ***