*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UZ2996050
CHEMICAL NAME           : Quaternary ammonium compounds,
                          benzyl-C8-C18-alkyldimethyl, chlorides
LAST UPDATED            : 199110
DATA ITEMS CITED        : 10
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Benzyl-C8-C18-alkyldimethyl ammonium chlorides
   * Catamin AB
   * Catamine AB
   * Onyx BTC
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - coma
REFERENCE :
   DZGGAK Deutsche Zeitschrift fuer die Gesamte Gerichtliche Medizin.
   (Heidelberg, Fed. Rep. Ger.) V.1-66, 1922-69.  For publisher information,
   see ZRMDAN.  Volume(issue)/page/year: 41,297,1952
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Blood - hemorrhage
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 12,1593,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1560 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Blood - hemorrhage
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 12,1593,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Blood - hemorrhage
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 12,1593,1978
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   DZGGAK Deutsche Zeitschrift fuer die Gesamte Gerichtliche Medizin.
   (Heidelberg, Fed. Rep. Ger.) V.1-66, 1922-69.  For publisher information,
   see ZRMDAN.  Volume(issue)/page/year: 41,297,1952
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DZGGAK Deutsche Zeitschrift fuer die Gesamte Gerichtliche Medizin.
   (Heidelberg, Fed. Rep. Ger.) V.1-66, 1922-69.  For publisher information,
   see ZRMDAN.  Volume(issue)/page/year: 41,297,1952
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
REFERENCE :
   SSCHAH Soap and Sanitary Chemicals.  (New York, NY)  V.14-30, 1938-54.  For
   publisher information, see SCCSC8.  Volume(issue)/page/year: 25,125,1949
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DZGGAK Deutsche Zeitschrift fuer die Gesamte Gerichtliche Medizin.
   (Heidelberg, Fed. Rep. Ger.) V.1-66, 1922-69.  For publisher information,
   see ZRMDAN.  Volume(issue)/page/year: 41,297,1952
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DZGGAK Deutsche Zeitschrift fuer die Gesamte Gerichtliche Medizin.
   (Heidelberg, Fed. Rep. Ger.) V.1-66, 1922-69.  For publisher information,
   see ZRMDAN.  Volume(issue)/page/year: 41,297,1952
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DZGGAK Deutsche Zeitschrift fuer die Gesamte Gerichtliche Medizin.
   (Heidelberg, Fed. Rep. Ger.) V.1-66, 1922-69.  For publisher information,
   see ZRMDAN.  Volume(issue)/page/year: 41,297,1952
 
                            *** END OF RECORD ***