*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY9453220
CHEMICAL NAME           : 4H-Pyrrolo(3,2-d)pyrimidin-4-one,
                          1,5-dihydro-2-amino-7-(3-thienylmethyl)-,
                          monohydrochloride,monohydrate
LAST UPDATED            : 199606
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C11-H10-N4-O-S.Cl-H.H2-O
MOLECULAR WEIGHT        : 300.79
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-Amino-7-(3-thenyl)-1,5-dihydro-4H-pyrrolo(3,2-d)pyrimidin-4-one  
   hydrochloride hydrate
   * CI 1000
   * PD 141955-2
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 mg/kg/2W-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Related to Chronic Data - death
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   28,51,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg/4W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
   Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   28,51,1995
 
                            *** END OF RECORD ***