*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY8545700
CHEMICAL NAME           : 5H-Pyrrolo(2,1-c)(1,4)benzodiazepin-5-one,
                          1,2,3,11a-tetrahydro-3,8-dihydroxy-7-methoxy-,
                          (3R-cis)-
CAS REGISTRY NUMBER     : 59593-15-6
LAST UPDATED            : 199204
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C13-H14-N2-O4.1/2H2-O
MOLECULAR WEIGHT        : 271.27
WISWESSER LINE NOTATION : T C576 BVN IN GHT&&J DQ LQ MO1
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Neothramycin B
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 2,1299,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 29,93,1976
 
                            *** END OF RECORD ***