*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY7430000
CHEMICAL NAME           : 3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-,
                          cmpd. with N,N'-dibenzyl- ethylene diamine (2:1), L-
CAS REGISTRY NUMBER     : 63717-00-0
LAST UPDATED            : 199606
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C20-H30-N2-O6.C16-H20-N2
MOLECULAR WEIGHT        : 634.90
WISWESSER LINE NOTATION : T5MV EHJ CV1 DQ E1Y1&1 2 &R1M2M1R
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * DBED tenuazonate
   * NSC-82260
   * 2H-Pyrrol-2-one, 3-acetyl-5-(1,1-dimethylethyl)-1,5-dihydro-4-hydroxy-,  
   N,N-dibenzylethylene
   * Tenuazonic acid, N,N'-dibenzylethylene diamine salt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 209 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 52,579,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 83 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 52,579,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 182 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 52,579,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 76 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 52,579,1968
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 44800 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,112,1965
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 190 mg/kg/17D-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - hemorrhage
   Related to Chronic Data - death
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 52,579,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 213 mg/kg/19D-I
TOXIC EFFECTS :
   Gastrointestinal - necrotic changes
   Blood - hemorrhage
   Related to Chronic Data - death
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 52,579,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 1053 mg/kg/32D-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - hemorrhage
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 52,579,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 134 mg/kg/6D-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - hemorrhage
   Related to Chronic Data - death
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,112,1965
 
                            *** END OF RECORD ***