*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UY7430000 CHEMICAL NAME : 3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, cmpd. with N,N'-dibenzyl- ethylene diamine (2:1), L- CAS REGISTRY NUMBER : 63717-00-0 LAST UPDATED : 199606 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C20-H30-N2-O6.C16-H20-N2 MOLECULAR WEIGHT : 634.90 WISWESSER LINE NOTATION : T5MV EHJ CV1 DQ E1Y1&1 2 &R1M2M1R COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * DBED tenuazonate * NSC-82260 * 2H-Pyrrol-2-one, 3-acetyl-5-(1,1-dimethylethyl)-1,5-dihydro-4-hydroxy-, N,N-dibenzylethylene * Tenuazonic acid, N,N'-dibenzylethylene diamine salt *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 209 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea REFERENCE : CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 83 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea REFERENCE : CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 182 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea REFERENCE : CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 76 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea REFERENCE : CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 44800 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,112,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 190 mg/kg/17D-I TOXIC EFFECTS : Gastrointestinal - other changes Blood - hemorrhage Related to Chronic Data - death REFERENCE : CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 213 mg/kg/19D-I TOXIC EFFECTS : Gastrointestinal - necrotic changes Blood - hemorrhage Related to Chronic Data - death REFERENCE : CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 1053 mg/kg/32D-I TOXIC EFFECTS : Gastrointestinal - other changes Blood - hemorrhage REFERENCE : CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 134 mg/kg/6D-I TOXIC EFFECTS : Gastrointestinal - other changes Blood - hemorrhage Related to Chronic Data - death REFERENCE : NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,112,1965 *** END OF RECORD ***