*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CB9394500
CHEMICAL NAME           : Antibiotic JA-20
CAS REGISTRY NUMBER     : 80701-11-7
LAST UPDATED            : 199604
DATA ITEMS CITED        : 6
SYNONYMS/TRADE NAMES :
   * JA-20
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 23,6,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 380 ug/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 23,6,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 23,6,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 23,6,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1950 ug/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 23,6,1981
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 750 mg/kg/30D-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Blood - changes in leukocyte (WBC) count
   Related to Chronic Data - changes in prostate weight
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 23,6,1981
 
                            *** END OF RECORD ***