*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CB9188000
CHEMICAL NAME           : Antibiotic A-21978 C(sub 3)
CAS REGISTRY NUMBER     : 74754-46-4
LAST UPDATED            : 199212
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C75-H107-N17-O26
MOLECULAR WEIGHT        : 1662.99
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * A-21978 C(sub 3)
   * Daptomycin, 1-(N-(10-methyl-1-oxododecyl)-L-tryptophan)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4208403
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 41,1093,1988
 
                            *** END OF RECORD ***