*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CB2687000
CHEMICAL NAME           : Anthranilic acid, N-(7-chloro-4-quinolyl)-,
                          2,3-dihydroxypropyl ester
CAS REGISTRY NUMBER     : 3820-67-5
BEILSTEIN REFERENCE NO. : 0497124
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H17-Cl-N2-O4
MOLECULAR WEIGHT        : 372.83
WISWESSER LINE NOTATION : T66 BNJ EMR CVO1YQ1Q& IG
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Alicidon
   * Benzoic acid, 2-((7-chloro-4-quinolinyl)amino)-, 2,3-dihydroxypropyl  
   ester
   * 4-((2-Carboxyphenyl)amino)-7-chloroquinoline alpha-monoglyceride
   *   4-(2'-(beta,gamma-Dihydroxypropoxycarbonyl)phenylamino)-7-chloroquinolei
     ne
   * 4-(2'-beta,gamma-Dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline
   * Dolomate
   * Glafenin
   * Glafenine
   * Glaphenin
   * Glaphenine
   * Glicafan
   * Glifan
   * Glifanan
   * Glifanar
   * Glycerylaminophenaquine
   * Privadol
   * R 1707
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2300 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 34,377,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1486 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 38,847,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 74 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 22,1343,1980
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 600 mg/kg/2D-I
TOXIC EFFECTS :
   Endocrine - changes in adrenal weight
   Blood - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   34,309,1975
 
                            *** END OF RECORD ***